hepatocellular carcinoma
Coverage of hepatocellular carcinoma in the Nexus archive.
- Coffee may have powerful effect on liver health, major study suggests
A major study published in Clinical Gastroenterology and Hepatology found that coffee consumption is linked to a significantly lower risk of severe liver disease, liver cancer, and liver-related death. The research, involving 354,957 UK Biobank participants over 13 years, showed that drinking 1-2 cups daily reduced cirrhosis risk by 20% and liver-related mortality by 31%, with higher consumption (5+ cups) offering even greater protection. Benefits were observed for both caffeinated and decaffeinated coffee, though adding sugar or artificial sweeteners weakened positive effects.
- That cup of coffee you had this morning may lower your risk for liver disease
A large study found that coffee consumption, including decaffeinated, may reduce risks of liver disease, cirrhosis, and liver cancer. The study tracked over 354,000 participants for more than a decade, showing higher coffee intake correlated with lower risks, though associations were not proven to be causal.
- Spermine is an endogenous iron chelator that inhibits ferroptosis
Spermine, an endogenous iron chelator, inhibits ferroptosis by limiting iron availability and lipid peroxidation. A non-canonical metabolic pathway involving ALDH18A1 is linked to spermine synthesis in hepatocellular carcinoma.