Dossier
ALDH18A1
Coverage of ALDH18A1 in the Nexus archive.
- Spermine is an endogenous iron chelator that inhibits ferroptosis
Spermine, an endogenous iron chelator, inhibits ferroptosis by limiting iron availability and lipid peroxidation. A non-canonical metabolic pathway involving ALDH18A1 is linked to spermine synthesis in hepatocellular carcinoma.