Dossier
GLP1R
Coverage of GLP1R in the Nexus archive.
- A brain reward circuit inhibited by next-generation weight-loss drugs in mice
Researchers investigated the neural circuitry of small-molecule GLP1R agonists in humanized glucagon-like peptide 1 receptor mouse models. The study found that next-generation weight-loss drugs inhibit a brain reward circuit in mice. This discovery has implications for how these orally delivered weight-loss drugs engage brain reward circuits.
- Genetics reveal why people respond differently to GLP-1 weight-loss drugs
A study published in Nature identifies genetic variants in GLP1R and GIPR genes as key factors influencing individual responses to GLP-1-based weight-loss drugs. These variants may explain varying drug effectiveness and potential adverse effects among patients.