Dossier
Glucagon-like peptide 1 receptor
Coverage of Glucagon-like peptide 1 receptor in the Nexus archive.
- A brain reward circuit inhibited by next-generation weight-loss drugs in mice
Researchers investigated the neural circuitry of small-molecule GLP1R agonists in humanized glucagon-like peptide 1 receptor mouse models. The study found that next-generation weight-loss drugs inhibit a brain reward circuit in mice. This discovery has implications for how these orally delivered weight-loss drugs engage brain reward circuits.