Dossier
GIPR
Coverage of GIPR in the Nexus archive.
- GLP-1R–GIPR–PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice
A single-molecule agonist targeting GLP-1R, GIPR, and PPARα/γ/δ receptors (GLP-1–GIP–lanifibranor) demonstrates therapeutic efficacy in correcting obesity and diabetes in mouse models through synergistic metabolic pathways. Published in Nature, the study highlights its potential for treating obesity-linked metabolic dysfunction.
- Genetics reveal why people respond differently to GLP-1 weight-loss drugs
A study published in Nature identifies genetic variants in GLP1R and GIPR genes as key factors influencing individual responses to GLP-1-based weight-loss drugs. These variants may explain varying drug effectiveness and potential adverse effects among patients.