Ferroptosis

Spermine, an endogenous iron chelator, inhibits ferroptosis by limiting iron availability and lipid peroxidation. A non-canonical metabolic pathway involving ALDH18A1 is linked to spermine synthesis in hepatocellular carcinoma.

Scientists have discovered that vitamin B2 may help cancer cells survive by supporting a cellular shield that protects tumors from ferroptosis. Researchers used a vitamin B2-like compound to break down this protection and trigger cancer cell death in lab tests. This finding highlights a potential dark side to vitamin B2.