DNA damage
Coverage of DNA damage in the Nexus archive.
- MIT study finds children more vulnerable to cancer-causing chemical in water
An MIT study reveals that NDMA, a chemical found in polluted water, medications, and processed foods, poses a higher cancer risk to children than adults. Experiments on mice showed that children's rapid cell division converts early DNA damage into mutations more easily, leading to increased cancer development despite equal exposure.
- DNA damage drives antigen diversification in Trypanosoma brucei
A study published in Nature reveals that DNA damage drives antigen diversification in Trypanosoma brucei, enabling the parasite to evade immune responses. Researchers developed an in vitro toolkit to understand molecular mechanisms behind mosaic VSG formation, offering insights into antigen diversification strategies in pathogens.
- DNA damage burden causes selective CUX2 neuron loss in neuroinflammation
A study published in Nature reveals that DNA damage burden and inadequate repair in CUX2+ cortical layer 2/3 excitatory neurons contribute to selective vulnerability in neuroinflammatory injury. The research highlights the role of DNA damage mechanisms in neuron loss during neuroinflammation, offering potential insights for therapeutic interventions.