SCIENCEJun 3 · 00:00 UTCNATURE NEWSRoberto Zoncu

LASER couples damage sensing to ESCRT assembly for lysosome repair

ATG8 conjugation on damaged lysosomes triggers rapid assembly of a protein complex containing TFG, which recruits ESCRT proteins to repair lysosomal membranes. This process links damage sensing to ESCRT-mediated lysosome repair.

Nexus surfaces and summarizes. The full story lives at the source.

Mentioned

ATG8 conjugationtopiclysosomestopicTFG protein complextopicESCRT proteinstopiclysosomal membrane repairtopic

Spot something wrong with this article?Report a problem →

Forward this