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The Nexus
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claudin-4

Coverage of claudin-4 in the Nexus archive.

Earliest in view: Apr 22 · 00:00 UTCMost recent: Jul 16 · 05:37 UTC
Co-mentioned in this coverage
bacterial toxintopic1colorectal cancertopic1decoy proteintopic1micetopic1Bacteroides fragilis toxintopic1E-cadherintopic1CRISPR screeningtopic1colonic epithelial cellstopic1Natureorganization1
Recent coverage
  • HEALTHJul 16 · 05:37 UTCSCIENCE DAILY
    Scientists finally solved how a common gut bacterium triggers colon cancer

    Researchers discovered that a bacterial toxin linked to colorectal cancer binds to the claudin-4 receptor to damage the colon's protective barrier. They developed a decoy protein that blocked the toxin in mice, potentially leading to new therapies for preventing inflammation and colon tumors.

  • SCIENCEApr 22 · 00:00 UTCNATURE NEWS
    A pro-carcinogenic bacterial toxin binds claudin-4 to cleave E-cadherin

    A study published in Nature identifies claudin-4 as a receptor for the pro-carcinogenic toxin from Bacteroides fragilis. The toxin's interaction with claudin-4 on colonic epithelial cells leads to E-cadherin cleavage, disrupting epithelial barriers and causing inflammation.