cellular senescence
Coverage of cellular senescence in the Nexus archive.
- Why “reprogramming” is the buzziest approach to reversing aging right now
Life Biosciences has initiated a trial testing an experimental treatment for glaucoma by injecting a reprogramming therapy into a volunteer's eye to regenerate healthy nerves. The approach aims to reverse aging by resetting cells to a younger state, building on past strategies like targeting telomere attrition and cellular senescence, though recent trials of senescence clearance in humans showed mixed results.
- Common eating habit may trigger premature immune system aging, study finds
A study from the University of South Alabama found that a high-salt diet triggers the immune system to release interleukin-16 (IL-16), causing premature aging of blood vessel cells and impairing their function. Experimental senolytic drugs like navitoclax reversed this damage in mice but face challenges in human application.