base editing
Coverage of base editing in the Nexus archive.
- Opinion: New human embryo editing advances require tough conversations on ethical boundaries
The article discusses recent advances in human embryo genome editing using CRISPR technology, including a new preprint on base editing from Dieter Egli's lab at Columbia. Despite these scientific developments, ethical questions about the use of such technologies remain unresolved.
- First precise genome editing of human embryos triggers praise and alarm
A study published in Nature details the first use of 'base editing' in early human embryos. The lead scientist states the technique is not yet ready for clinical use, while critics express concerns about potential commercialization.
- Clinical application of base editing for treating β-thalassaemia
A phase 1 clinical trial using CS-101, CD34+ cells modified with a transformer base editor, showed early and sustained transfusion independence in β-thalassaemia patients. The treatment reactivates fetal hemoglobin production, offering a potential breakthrough in genetic disorder therapy.