Dossier
animal models
Coverage of animal models in the Nexus archive.
- A single protein may be holding back CAR T cancer therapy
A newly identified protein called NFIL3 is found to cause CAR T-cell therapy to lose effectiveness over time by inducing exhaustion in engineered immune cells. Disabling NFIL3 in animal models improved the cells' strength and tumor control.
- Two common drugs may reverse fatty liver disease, study finds
Scientists found that combining two existing drugs can significantly reduce liver fat associated with a common, often silent disease in animal models. The treatment also showed potential to lower heart-related risks and worked effectively with lower doses. However, human trials are needed to confirm these findings.