Chromatin accessibility
Coverage of Chromatin accessibility in the Nexus archive.
- Multiomics and deep learning dissect regulatory syntax in human development
A new study published in Nature introduces the Human Development Multiomic Atlas, which integrates single-cell data from 12 fetal organs to uncover regulatory rules governing transcription factor binding and chromatin accessibility during human development. The research combines multiomics and deep learning to map cell-type-specific genetic mechanisms.
- Gene regulatory landscape dissected by single-cell four-omics sequencing
A study published in Nature on April 1, 2026, employs single-cell four-omics sequencing to analyze genome conformation, histone modifications, chromatin accessibility, and gene expression. This approach reveals dynamic epigenome profiles and spatial clustering within cells, advancing understanding of regulatory landscapes across tissues.