Dossier
Antifungal resistance
Coverage of Antifungal resistance in the Nexus archive.
- Antifungal resistance is growing – will new treatments turn the tables?
Antifungal resistance is growing and new treatments are being developed to fight deadly resistant infections, but these treatments may fall victim to overuse of agricultural fungicides. Trials of drugs to combat these infections are advancing. The growth of antifungal resistance poses a significant threat to public health.
- Structural basis of fungal β-1,3-glucan synthase inhibition by caspofungin
A study published in Nature reveals the structural basis of how caspofungin inhibits fungal β-1,3-d-glucan synthase. This discovery could enable the development of next-generation echinocandins with enhanced potency, broader antifungal activity, and reduced resistance risks.