Dossier
next-generation echinocandins
Coverage of next-generation echinocandins in the Nexus archive.
- Structural basis of fungal β-1,3-glucan synthase inhibition by caspofungin
A study published in Nature reveals the structural basis of how caspofungin inhibits fungal β-1,3-d-glucan synthase. This discovery could enable the development of next-generation echinocandins with enhanced potency, broader antifungal activity, and reduced resistance risks.