Cell-type-resolved genetic variation shapes inflammatory bowel disease risk

A study published in Nature reveals that cell-type-specific genetic variants in inflammatory bowel disease (IBD) co-localize more frequently with genome-wide association study (GWAS) loci when analyzed at the cell-type level compared to the tissue level. Single-cell mapping of cis-expression quantitative trait loci (cis-eQTLs) identified distal, enhancer-enriched variants linked to IBD risk.