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The article poses the question of who will lead the FDA and mentions STAT's free health newsletter, Morning Rounds, while referencing a World Cup match between France and Morocco.

Northwest Biotherapeutics submitted a marketing application for its brain cancer treatment DCVax to U.K. regulators in late December 2023 under an expedited pathway expecting a 150-day review. Over 931 days later, the U.K.’s Medicines and Healthcare products Regulatory Agency (MHRA) has not approved the drug and refuses to comment, deferring updates to the company.

AstraZeneca and Ionis Pharmaceuticals reported that their heart disease drug, Wainua, failed in a pivotal trial for ATTR-CM, showing no improvement over placebo in reducing cardiovascular death and clinical events. The failure caused AstraZeneca's U.S. shares to drop 8% and London-listed shares to fall 9%, while Ionis shares fell 12%.

The Great American State Fair in Washington concludes with two 'MAHA Mondays' events featuring speakers from the Make America Healthy Again movement. Health and Human Services senior adviser Calley Means and acting Surgeon General Stephanie Haridopolos discussed health and wellness and a recent advisory on screen use harms.

Matt Wilsey developed a gene therapy to treat his daughter Grace's NGLY1 deficiency, an ultra-rare genetic disorder, but the treatment caused her to be hospitalized. Wilsey's efforts, which involved assembling scientists and advocates, aim to create a model for curing other rare diseases.

The article discusses how drugmakers like Eli Lilly and Novo Nordisk promote classifying obesity as a chronic disease to justify long-term medical treatments. They cite the World Health Organization's recognition of obesity as a disease, aiming to frame it as a medical problem requiring pharmaceutical solutions.

The article describes an incident where a 70-year-old woman experienced a cannabis-related emergency after legalization in Massachusetts in 2016, highlighting the need for medical guidance for elderly users. A doctor at the scene provided care during her episode.

Health secretary Robert F. Kennedy Jr. plans to compile a list of injuries presumed to be caused by Covid-19 vaccines, enabling individuals to seek government compensation. He criticizes vaccines for lacking adequate safety testing and aims to overhaul a program that compensates those injured by federally recommended vaccines. Experts are monitoring which conditions may be included on the list.

The White House is reviewing top contenders to lead the FDA, including Heidi Overton, Jeffrey Vacirca, and Stephen Ferrara. These individuals are under final consideration for the role.

Trump administration officials, including Secretary of State Marco Rubio and health secretary Robert F. Kennedy Jr., urged pharmaceutical leaders in a private meeting to bring production of essential medications back to the U.S. The discussion focused on strengthening U.S. control over supply chains for 86 medicines deemed essential by the health department’s Assistant Secretary for Preparedness and Response.

Longevity entrepreneur Bryan Johnson has been diagnosed with autoimmune gastritis, a chronic condition where the body's antibodies attack stomach cells, impairing iron absorption. The disease increases the risk of stomach cancer and can lead to vitamin B12 deficiencies causing anemia and neurological issues.

The FDA approved Trutakna, a kidney disease drug from Vera Therapeutics, for treating IgA nephropathy at an annual price of $425,000. U.K. officials are finalizing a pricing deal with AstraZeneca and Daiichi Sankyo to provide access to Enhertu, a breast cancer drug previously deemed too costly for the U.K. market.

The article mentions an upcoming significant increase in premiums and references a historical event related to the Declaration of Independence. It also promotes STAT’s free health and medicine newsletter, Morning Rounds.

The Trump administration implemented significant changes to science policy, including terminating funded projects and altering university reimbursement practices, which faced legal challenges leading to policy reversals. Federal civil servants and academic researchers were affected, with courts citing violations of the Administrative Procedures Act.

In the United States, children aged 2 and older can now obtain a continuous glucose monitor (CGM) without a doctor’s prescription. The Food and Drug Administration (FDA) supports this change, highlighting the potential benefits of CGMs for young children.

A cardiologist overrides an AI algorithm's diagnosis after reviewing an echocardiogram, highlighting concerns about accountability when AI systems are used in healthcare. The article argues that current licensure practices place liability on clinicians rather than AI developers or health systems deploying the technology.

Doug, a retired minister, experienced reduced boredom through conversations with Jane, an AI chatbot, which provided meaningful engagement for him and eased the burden on his wife Gabriella. The article explores the role of AI in dementia care, highlighting how the chatbot offered a solution to Doug's persistent boredom.

The FDA approved Trutakna, a new treatment for IgA nephropathy, a chronic autoimmune kidney disease, developed by Vera Therapeutics. Vera CEO Marshall Fordyce expressed excitement about bringing the drug to patients.

A 'secret shopper' study investigates GLP-1 telehealth sites, as STAT's Health Tech newsletter highlights rising healthcare costs through a new series. The article focuses on technology's role in transforming life sciences and explores the financial burden of healthcare despite employer-provided insurance.

Vertex Pharmaceuticals acquired Crinetics Pharmaceuticals for $10 billion, gaining access to Palsonify, a drug for acromegaly, and other drug candidates. The deal marks Vertex's largest acquisition as it expands beyond its cystic fibrosis portfolio.