Dossier
multiancestry cohorts
Coverage of multiancestry cohorts in the Nexus archive.
- Distinct genetic architecture in the tails of complex traits
A study published in Nature on May 27, 2026, reveals that rare genetic alleles have disproportionately larger effects on the extreme ends of complex trait distributions compared to common alleles. Genome-wide analyses in multiancestry and European cohorts support this finding, highlighting distinct genetic architecture at phenotypic tails.