epigenetic reprogramming
Coverage of epigenetic reprogramming in the Nexus archive.
- Longevity medicine's do-or-die moment
The first human trial of an experimental gene therapy aims to test the safety of cellular reprogramming to rejuvenate aging cells, with initial focus on treating glaucoma. The trial, sponsored by Life Biosciences co-founded by David Sinclair, represents a critical step in validating the potential of epigenetic reprogramming to address age-related diseases.
- David Sinclair plans to test whole-body rejuvenation drugs in the XPrize competition
David Sinclair, a longevity scientist, plans to test an oral reprogramming drug in human trials as part of a $101 million XPrize competition aimed at restoring apparent age through improvements in immune, cognitive, and muscle function. His Harvard-affiliated work involves epigenetic reprogramming, which resets molecular DNA controls, and his company Life Biosciences has already initiated gene therapy trials for eye conditions.