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age-related somatic mosaicism

Coverage of age-related somatic mosaicism in the Nexus archive.

Earliest in view: May 27 · 00:00 UTCMost recent: May 27 · 00:00 UTC
Co-mentioned in this coverage
Natureorganization1mitochondrial DNA mutationstopic1cryptic replication errorstopic1passenger mutationstopic1oxidative damagetopic1
Recent coverage
  • SCIENCEMay 27 · 00:00 UTCNATURE NEWS
    Mechanism of age-related accumulation of mtDNA mutations in human blood

    A study published in Nature reveals that age-related accumulation of mitochondrial DNA (mtDNA) mutations in human blood is primarily caused by cryptic replication errors acting as passenger mutations, which become detectable with age due to somatic mosaicism, rather than oxidative damage. This challenges previous assumptions about the role of oxidative stress in mtDNA mutation accumulation.

age-related somatic mosaicism · Dossier · The Nexus