LDL
Coverage of LDL in the Nexus archive.
- Ask Dr. Nandi: What new guidelines could mean for how young adults manage 'bad' cholesterol
New guidelines expand statin eligibility to adults as young as 30, lowering cardiovascular risk thresholds and considering 30-year risk. A study estimates 21.5 million more Americans may qualify for statin therapy to prevent heart attacks or strokes, based on health data from 4,300 adults aged 30-79. The guidelines emphasize consulting doctors to assess individual risk factors like high LDL, diabetes, or family history.
- What is the new FDA-approved pill designed to slash cholesterol levels?
The FDA has approved a new pill called Lipfendra, which clinical trials show can reduce LDL cholesterol levels by 60%. The drug targets LDL, the 'bad' type of cholesterol.
- Bad cholesterol slashed 62% by single dose of gene-editing drug in small trial
An experimental gene-editing drug, VERVE-102, showed a 62% reduction in LDL cholesterol in a Phase I trial with 35 patients, with no serious adverse events reported. The treatment demonstrated sustained effectiveness over 18 months, though a temporary mild liver enzyme increase was observed.