Genetic variants
Coverage of Genetic variants in the Nexus archive.
- Long-lived families reveal a rare genetic clue to healthy aging
A study of long-lived families has identified rare genetic variants that may help people stay healthier for longer as they age. One mutation appears to reduce inflammation, potentially delaying disease and extending healthy lifespan.
- Scientists discover why ozempic may not work for some people
Scientists have identified genetic variants that may reduce the effectiveness of GLP-1 drugs for treating Type 2 diabetes in about 10% of the population. These variants appear to cause 'GLP-1 resistance,' making carriers less likely to achieve healthy blood sugar targets during clinical trials of these medications.
- Why Ozempic doesn’t work for everyone: Scientists just found a hidden reason
A new study identifies that 10% of people may not respond to Ozempic and Wegovy due to genetic variants causing GLP-1 resistance. The condition involves elevated GLP-1 hormone levels without proper response to the drugs.
- Genetic predictors of GLP1 receptor agonist weight loss and side effects
A study published in Nature identifies genetic variants linked to the effectiveness and side effects of GLP1 receptor agonist medications. These findings could advance precision medicine strategies for obesity treatment by enabling personalized therapeutic approaches.
- Why obesity drugs work better for some people: these genes hold clues
A study of nearly 28,000 people reveals genetic factors influencing the effectiveness of obesity drugs and their gastrointestinal side effects. Researchers identified specific genetic variants linked to varying responses to GLP-1 medications.