Dossier
GAGE-seq
Coverage of GAGE-seq in the Nexus archive.
- Genetic clue could lead to future Alzheimer’s treatments
Researchers found Alzheimer’s disease alters the three-dimensional organization of DNA in brain cells, linking genomic reorganization to changes in genetic activity and cell arrangement. The study, using single-cell technology and AI models like Hicformer, analyzed post-mortem brain tissue to uncover how genome folding relates to gene regulation in Alzheimer’s patients.