Dossier
Fibroblast Subtypes
Coverage of Fibroblast Subtypes in the Nexus archive.
- Emergence of oncofetal plasticity is ubiquitous in early colorectal cancers
The study reveals that metastasis-associated oncofetal cell states appear in early colorectal cancers, with spatial profiling showing fibroblast subtypes resembling normal tissue architecture. These distinct regional microenvironments influence the timing and positioning of oncofetal plasticity, offering new insights into cancer progression mechanisms.