Dossier
Cochrane review
Coverage of Cochrane review in the Nexus archive.
- Alzheimer’s drugs slammed as ‘ineffective’ in major review, but critics push back
A major Cochrane review found that amyloid-targeting Alzheimer's drugs have little to no effect on memory decline and dementia severity. The review analyzed results from 17 clinical trials involving over 20,000 participants. Researchers concluded that lowering amyloid-beta alone is unlikely to produce meaningful clinical gains.