B cells
Coverage of B cells in the Nexus archive.
- Hard-to-detect mutations explain how common autoimmune diseases arise
Advanced DNA sequencing has provided new evidence supporting an old theory about autoimmune diseases, revealing rare mutations in B cells linked to autoimmune thyroid conditions. The study highlights how hard-to-detect genetic changes contribute to common autoimmune disorders.
- DNA-folding changes block production of self-directed antibodies
DNA-folding changes can block the production of self-directed antibodies. This is due to DNA rearrangements in immune-system B cells, which generate diverse antibody-encoding genes. The process helps avoid producing antibodies that target the body's own tissues.
- A cell atlas charts the immune architecture of diabetic kidney disease
A study published in Nature uses single-cell gene-expression profiling and spatial mapping to identify immune microenvironments in diabetic kidney disease, particularly highlighting aggregated B cells in patients with accelerated disease progression.
- Daily briefing: Immune cells have a surprising role in exercise endurance
A study in Nature reveals that B cells play a crucial role in supporting muscles during exercise in mice, challenging previous assumptions. The article also mentions the winners of the 2026 Breakthrough Prizes and tips for debugging scientific software.
- Immune cells have a surprising role in exercise endurance
A study published in Nature on April 17, 2026, reveals that B cells in mice play a role in regulating muscle performance during exercise. This finding challenges previous assumptions about immune cell functions and suggests potential links between immunity and physical endurance.